4494 Mission Street is much more than a 2,500 square foot commercial property with two car parking. It was the home of Central Drug Store'' for 116 years before it shuttered in 2025. Before closing, Central Drug was lovingly operated by the same family for over 60 years. It is now time for the family to move on, welcoming a new owner to start their legacy. Located on the corner of Mission Street and Santa Rosa Avenue in the Excelsior district, the building has prominent street frontage and ample foot traffic. The open floor plan holds 1,300 +/- sq/ft on the ground floor (including garage) plus a 525 +/- sq/ft mezzanine, and approx. 10 ft. ceiling. Two separate garages enter from Santa Rosa Avenue. The lot is zoned NCD-Excelsior. A feasibility study suggests that zoning may allow development of up to 10 units and over 9,500 sq/ft +/- of buildable space. Interested buyers/agents are advised to review disclosures and consult their own professionals. 4494 Mission Street is ready for a new owner to start the next 100-year legacy project in the vibrant Excelsior District.
MLS #
SF426114877
MLS Source
San Francisco Association of Realtors® MLS
Days on Site
0
# Buildings / # Units
0 / 0
Parking Spaces
2
Present Use
Retail
Utilities
Water - Public
Flooring
Concrete
Cooling
None
Sewer
Public Sewer
Water
Public
Zoning
COM-NEC
| # Buildings | # Leased Units | # Total Units |
|---|---|---|
| 0 | – | 0 |
4494 Mission St is a Commercial Sale in San Francisco, CA 94132. This 2,495 square foot property sits on a 2,495 Sq Ft Lot and features – bedrooms & – full bathrooms. It is currently priced at $1,150,000 and was built in 1910. This address can also be written as 4494 Mission St, San Francisco, CA 94132.
©2026 San Francisco Association of Realtors® MLS. All rights reserved. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information. Information provided is for personal, non-commercial use by the viewer and may not be redistributed without explicit authorization from San Francisco Association of Realtors® MLS.
Presently MLSListings.com displays Active, Contingent, Pending, and Recently Sold listings. Recently Sold listings are properties which were sold within the last three years. After that period listings are no longer displayed in MLSListings.com. Pending listings are properties under contract and no longer available for sale. Contingent listings are properties where there is an accepted offer, and seller may be seeking back-up offers. Active listings are available for sale.
This listing information is up-to-date as of March 26, 2026. For the most current information, please contact John Antonini, (415) 794-9510